FORMULASI DAN UJI AKTIVITAS ANTIPENUAAN SPRAY GEL KOMBINASI EKSTRAK KULIT SALAK DAN LIDAH BUAYA
Keywords:
spray gel, snakefruit rind, aloe vera, anti aging
spray gel, snakefruit rind, aloe vera, anti aging
Abstract
Exposure to ultraviolet light contains ROS that cause skin damage and premature aging. Spray gel with natural antioxidants can be used to prevent premature aging. This study aims to formulate and test the anti-aging activity of spray gel combination of snakefruit rind and aloe vera extracts. Spray gel was made in 6 formulas with different extract concentrations then physicochemical evaluation and in vivo anti-aging activity test were conducted. The results showed that the spray gel had a viscous liquid form, white to brownish yellow colour, oleum rosae odour, homogeneous, pH 3.3-4, viscosity 1,191-6,263 cps and average weight per spray ranging from 0.43±0.15 to 0.75±0.24. The percentage of collagen density with ImageJ Software in group F1 was 30.21%, group F2 7.34%, group F3 21.09%, group F4 7.48%, group F5 12.03% and group F6 5.25%. The combination of snakefruit extract and aloe vera extract can be formulated into an anti-aging spray gel that has good organoleptic characteristics, homogeneity, viscosity and spray pattern, but the pH value does not meet safety standards. Spray gel with natural antioxidants can be used to prevent premature aging.
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References
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Dumanović, J. et al. (2021) ‘The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview’, Frontiers in Plant Science, 11(January), pp. 1–13. Available at: https://doi.org/10.3389/fpls.2020.552969.
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Martono, C. and Suharyani, I. (2018) ‘Formulasi Sediaan Spray Gel Antiseptik dari Ekstrak Etanol Lidah Buaya (Aloe vera)’, Jurnal Farmasi Muhammadiya Kuningan, 3(1), pp. 29–37. Available at: http://ojs.stikes-muhammadiyahku.ac.id/index.php/jurnalfarmaku/article/view/55.
Murti, D.A., Salim, M.N. and Sabri, M. (2017) ‘Efektifitas Salep Getah Jarak Pagar (Jatropha curcas L) pada Fase Epitelisasi Penyembuhan Luka Sayat Kulit Mencit (mus musculus) dengan Pewarnaan Masson Trichrome’, Jimvet, 01(3), pp. 465–472.
Nasution, N. (2015) Uji Aktivitas Ekstrak Etanol Umbi Talas Jepang (Colocasia esculenta (L.) Schott var. antiquorum) terhadap Penyembuhan Luka Terbuka pada Tikus Putih (Rattus norvegicus) Jantan Galur Sprague Dawley. UIN Syarif Hidayatullah Jakarta. Available at: https://repository.uinjkt.ac.id/dspace/bitstream/123456789/29270/1/NURHAYATI NASUTION-FKIK.pdf.
Nisak, K. (2016) Uji Stabilitas Fisik dan Kimia Sediaan Gel Semprot Ekstrak Etanol Tumbuhan Paku (Nephrolepis falcata (Cav.) C. Chr.), UIN Syarif Hidayatullah Jakarta. UIN Syarif Hidayatullah Jakarta.
Parrado, C. et al. (2019) ‘Environmental Stressors on Skin Aging. Mechanistic Insights’, Frontiers in Pharmacology, 10(759), pp. 1–17. Available at: https://doi.org/10.3389/fphar.2019.00759.
Passeron, T. et al. (2020) ‘Clinical and Biological Impact of The Exposome on The Skin’, Journal of the European Academy of Dermatology and Venereology, 34(S4), pp. 4–25. Available at: https://doi.org/10.1111/jdv.16614.
Pawarti, N. et al. (2023) ‘Pengaruh Metode Ekstraksi Terhadap Persen Rendemen dan Kadar Fenolik Ekstrak Tanaman yang Berpotensi sebagai Antioksidan’, Medula, 13(4), pp. 590–593.
Puspita, W., Puspasari, H. and Restanti, N.A. (2020) ‘Formulasi Dan Pengujian Sifat Fisik Sediaan Spray Gel Ekstrak Etanol Daun Buas-Buas (Premna Serratifolia L.)’, Jurnal Ilmiah Farmako Bahari, 11(2), p. 145. Available at: https://doi.org/10.52434/jfb.v11i2.798.
Regina, O., Sudrajad, H. and Syaflita, D. (2018) ‘Measurement of Viscosity Uses an Alternative Viscometer’, Jurnal Geliga Sains: Jurnal Pendidikan Fisika, 6(2), pp. 127–132. Available at: https://doi.org/10.31258/jgs.6.2.127-132.
Ritonga, M.A. (2022) Pengaruh Pemberian Krim Ekstrak Cascara Pulp Kopi Arabika Gayo terhadap Ketebalan dan Kepadatan Kulit Tikus Putih (Rattus Norvegicus) yang Dipapar Sinar UV-B. Universitas Syiah Kuala Darussalam Banda Aceh. Available at: https://ruangbaca.fk.usk.ac.id/index.php?p=show_detail&id=1739.
Robbiyan;, Pandapotan, M.M. and Apriani, R. (2021) ‘Penentuan Kadar Flavonoid Dari Ekstrak Kulit Salak (Salacca zalacca, Reinw) Berdasarkan Perbedaan Pengeringan Simplisia’, Lantanida Journal, 9(1), pp. 1–12.
Safitri, F.I., Nawangsari, D. and Febrina, D. (2021) ‘Overview: Application of Carbopol 940 in Gel’, in Proceedings of The International Conference on Helath and Medical Sciences (AHMS 2020), pp. 80–84. Available at: https://doi.org/10.2991/ahsr.k.210127.018.
Saputri, R.K. and Al-bari, A. (2023) ‘Karakteristik dan Uji Antioksidan Sabun Transparan Ekstrak Kulit Salak Wedi’, Forte Journal, 03(2), pp. 183–191. Available at: https://www.ojs.unhaj.ac.id/index.php/fj.
Saputri, R.K., Albari, A. and Nisak, S.C. (2022) ‘Pengaruh Basis Minyak Terhadap Karakteristik dan Daya Bersih Sabun Transparan Ekstrak Kulit Salak (Salacca zalacca)’, Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), pp. 91–100. Available at: https://doi.org/10.37874/ms.v7i2.311.
Septiawan, A.N., Emelda, E. and Husein, S. (2021) ‘Aktivitas Antioksidan Kombinasi Ekstrak Etanol (Aloe vera L.) dan Ganggang Hijau (Ulva lactuca L.)’, INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal), 4(1), pp. 11–24. Available at: https://doi.org/10.21927/inpharnmed.v4i1.1601.
Tenti, D.C. (2019) Aktivitas Jus Buah Dewandaru terhadap Kepadatan Kolagen pada Mencit (Eugenia uniflora) Jantan. Akademi Farmasi Putera Indonesia Malang.
Tutik, T. et al. (2021) ‘Formulasi Sediaan Gel Moisturizer Anti-aging Ekstrak Kulit Bawang Merah (Alliium cepa L.) sebagai AntioksidanN’, Jurnal Farmasi Malahayati, 4(1), pp. 93–106. Available at: https://doi.org/10.33024/jfm.v4i1.4420.
Wahid, H., Karim, S.F. and Sari, N. (2022) ‘Formulasi Sediaan Krim Anti-aging dari Ekstrak Kolagen Limbah Sisik Ikan Bandeng (Chanos chanos)’, Jurnal Sains dan Kesehatan, 4(4), pp. 428–436. Available at: https://doi.org/10.25026/jsk.v4i4.1289.
Wijaya, H., Novitasari and Jubaidah, S. (2018) ‘Perbandingan Metode Ekstraksi Terhadap Rendemen Ekstrak Daun Rambui Laut (Sonneratia caseolaris L. Engl)’, Jurnal Ilmiah Manuntung, 4(1), pp. 79–83.
Zubaydah, W.O.S., Novianti, R. and Indalifiany, A. (2022) ‘Pengembangan dan pengujian sifat fisik sediaan spray gel darı ekstrak etanol batang Etlıngera rubroloba menggunakan basıs gel Na-CMC’, Journal Borneo, 2(2), pp. 38–49. Available at: https://doi.org/10.57174/jborn.v2i2.27.
Alifah, D. and Susilawati, Y. (2018) ‘Review Artikel : Potensi Tumbuhan Sebagai Anti Aging’, Farmaka, 16(2), pp. 581–590.
Amalia, M.N. (2018) Aktivitas Antioksidan Emulgel Gamma Oryzanol Sebagai Anti Aging Terhadap Mencit Yang Dipapar Sinar Ultraviolet B, UIN Syarif Hidayatullah Jakarta. UIN Syarif Hidayatullah Jakarta. Available at: https://doi.org/10.1016/j.jns.2018.09.022%0Ahttp://dx.doi.org/10.1016/j.ejphar.2009.04.058%0Ahttp://dx.doi.org/10.1016/j.brainres.2015.10.001%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2854659&tool=pmcentrez&rendertype=abstract%0Ahttp://www.pub.
Angelia, A. et al. (2022) ‘Formulasi Sediaan Spray Gel Ekstrak Kulit Jeruk Manis (Citrus Sinensis L.) sebagai Anti-Aging’, Generics: Journal of Research in Pharmacy, 2(1), pp. 44–53. Available at: https://doi.org/10.14710/genres.v2i1.13213.
Asky, S., Rukaya, B.E. and Mustamin, F. (2022) ‘Uji Stabilitas Fisik Serum Anti-aging Ekstrak Etil Asetat Daun Cempedak (Arthocarpus champeden Spreng.)’, Journal Borneo, 2(2), pp. 50–58. Available at: https://doi.org/10.57174/jborn.v2i2.37.
Ati, S.I.S. (2023) Potensi Blemish Balm Cream Ekstrak Kulit Buah Salak (Salacca zalacca (Gaert.) Voss.) terhadap Ekspresi Gen TGF-β1, IL- 10, dan IL-18 pada Mencit (Mus musculus L.) yang Diinduksi Ultraviolet sebagai Model Penuaan. Universitas Pendidikan Indonesia.
Dumanović, J. et al. (2021) ‘The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview’, Frontiers in Plant Science, 11(January), pp. 1–13. Available at: https://doi.org/10.3389/fpls.2020.552969.
Fahlevi, R.I., Ramadhan, A.M. and Aryati, F. (2021) ‘Uji Stabilitas Kombinasi Gel Lidah Buaya (Aloe vera (L.) Webb) dan Madu dengan Menggunakan 2 Basis Na-CMC Berbeda’, in Mulawarman Pharmaceutical Conference. Samarinda: Universitas Mulawarman, pp. 159–163.
Ferreira, M.S. et al. (2021) ‘Trends in the Use of Botanicals in Anti-Aging CosmeticS’, Molecules, 26(3584), pp. 1–18.
Girsang, E. (2020) Kulit Salak Manfaat Bagi Kesehatan. Edited by C. Novalinda and I.N.E. Lister. UNPRI Press.
Hamid, M.K. (2017) Aktivitas Antipenuaan Ekstrak Air Daun Kersen (Muntingia calabura) terhadap Jumlah Fibroblas Kulit, Universitas Islam Indonesia. Universitas Islam Indonesia.
Jakubczyk, K. et al. (2020) ‘Chemical Profile and Antioxidant Activity of The Kombucha Beverage Derived from White, Green, Black and Red Tea’, Antioxidants, 9(447), pp. 1–15. Available at: https://doi.org/10.3390/antiox9050447.
Kresnawati, Y., Fitrianingsih, S. and Purwaningsih, C.P. (2022) ‘Formulasi Dan Uji Potensi Sediaan Spray Gel Niasiamida Dengan Propilenglikol Sebagai Humektan’, Cendekia Journal of Pharmacy, 6(2), pp. 281–290. Available at: https://doi.org/10.31596/cjp.v6i2.214.
Leonard, A.K. et al. (2019) ‘Methods for The Visualization and Analysis of Extracellular Matrix Protein Structure and Degradation’, Methods Cell Biol, 143(2018), pp. 79–95. Available at: https://doi.org/10.1016/bs.mcb.2017.08.005.Methods.
Mahadi, S.B. et al. (2019) ‘Antioxidant and Anti-tyrosinase Activities of Aloe vera Rind and Gel Extracts’, Global Medical & Health Communication (GMHC), 7(3), pp. 170–176. Available at: https://doi.org/10.29313/gmhc.v7i3.4453.
Marlina, D., Fadly and Fathya, Z. (2021) ‘Formulasi dan Evaluasi Spray Gel Anti Jerawat Ekstrak Kayu Secang (Caesalpinia sappan L.) dengan Variasi Konsentrasi Carbopol 940 Sebagai Gelling Agent’, Jurnal Kesehatan Pharmasi (JKPharm) Vol.3, 3(2), pp. 132–138.
Martono, C. and Suharyani, I. (2018) ‘Formulasi Sediaan Spray Gel Antiseptik dari Ekstrak Etanol Lidah Buaya (Aloe vera)’, Jurnal Farmasi Muhammadiya Kuningan, 3(1), pp. 29–37. Available at: http://ojs.stikes-muhammadiyahku.ac.id/index.php/jurnalfarmaku/article/view/55.
Murti, D.A., Salim, M.N. and Sabri, M. (2017) ‘Efektifitas Salep Getah Jarak Pagar (Jatropha curcas L) pada Fase Epitelisasi Penyembuhan Luka Sayat Kulit Mencit (mus musculus) dengan Pewarnaan Masson Trichrome’, Jimvet, 01(3), pp. 465–472.
Nasution, N. (2015) Uji Aktivitas Ekstrak Etanol Umbi Talas Jepang (Colocasia esculenta (L.) Schott var. antiquorum) terhadap Penyembuhan Luka Terbuka pada Tikus Putih (Rattus norvegicus) Jantan Galur Sprague Dawley. UIN Syarif Hidayatullah Jakarta. Available at: https://repository.uinjkt.ac.id/dspace/bitstream/123456789/29270/1/NURHAYATI NASUTION-FKIK.pdf.
Nisak, K. (2016) Uji Stabilitas Fisik dan Kimia Sediaan Gel Semprot Ekstrak Etanol Tumbuhan Paku (Nephrolepis falcata (Cav.) C. Chr.), UIN Syarif Hidayatullah Jakarta. UIN Syarif Hidayatullah Jakarta.
Parrado, C. et al. (2019) ‘Environmental Stressors on Skin Aging. Mechanistic Insights’, Frontiers in Pharmacology, 10(759), pp. 1–17. Available at: https://doi.org/10.3389/fphar.2019.00759.
Passeron, T. et al. (2020) ‘Clinical and Biological Impact of The Exposome on The Skin’, Journal of the European Academy of Dermatology and Venereology, 34(S4), pp. 4–25. Available at: https://doi.org/10.1111/jdv.16614.
Pawarti, N. et al. (2023) ‘Pengaruh Metode Ekstraksi Terhadap Persen Rendemen dan Kadar Fenolik Ekstrak Tanaman yang Berpotensi sebagai Antioksidan’, Medula, 13(4), pp. 590–593.
Puspita, W., Puspasari, H. and Restanti, N.A. (2020) ‘Formulasi Dan Pengujian Sifat Fisik Sediaan Spray Gel Ekstrak Etanol Daun Buas-Buas (Premna Serratifolia L.)’, Jurnal Ilmiah Farmako Bahari, 11(2), p. 145. Available at: https://doi.org/10.52434/jfb.v11i2.798.
Regina, O., Sudrajad, H. and Syaflita, D. (2018) ‘Measurement of Viscosity Uses an Alternative Viscometer’, Jurnal Geliga Sains: Jurnal Pendidikan Fisika, 6(2), pp. 127–132. Available at: https://doi.org/10.31258/jgs.6.2.127-132.
Ritonga, M.A. (2022) Pengaruh Pemberian Krim Ekstrak Cascara Pulp Kopi Arabika Gayo terhadap Ketebalan dan Kepadatan Kulit Tikus Putih (Rattus Norvegicus) yang Dipapar Sinar UV-B. Universitas Syiah Kuala Darussalam Banda Aceh. Available at: https://ruangbaca.fk.usk.ac.id/index.php?p=show_detail&id=1739.
Robbiyan;, Pandapotan, M.M. and Apriani, R. (2021) ‘Penentuan Kadar Flavonoid Dari Ekstrak Kulit Salak (Salacca zalacca, Reinw) Berdasarkan Perbedaan Pengeringan Simplisia’, Lantanida Journal, 9(1), pp. 1–12.
Safitri, F.I., Nawangsari, D. and Febrina, D. (2021) ‘Overview: Application of Carbopol 940 in Gel’, in Proceedings of The International Conference on Helath and Medical Sciences (AHMS 2020), pp. 80–84. Available at: https://doi.org/10.2991/ahsr.k.210127.018.
Saputri, R.K. and Al-bari, A. (2023) ‘Karakteristik dan Uji Antioksidan Sabun Transparan Ekstrak Kulit Salak Wedi’, Forte Journal, 03(2), pp. 183–191. Available at: https://www.ojs.unhaj.ac.id/index.php/fj.
Saputri, R.K., Albari, A. and Nisak, S.C. (2022) ‘Pengaruh Basis Minyak Terhadap Karakteristik dan Daya Bersih Sabun Transparan Ekstrak Kulit Salak (Salacca zalacca)’, Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), pp. 91–100. Available at: https://doi.org/10.37874/ms.v7i2.311.
Septiawan, A.N., Emelda, E. and Husein, S. (2021) ‘Aktivitas Antioksidan Kombinasi Ekstrak Etanol (Aloe vera L.) dan Ganggang Hijau (Ulva lactuca L.)’, INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal), 4(1), pp. 11–24. Available at: https://doi.org/10.21927/inpharnmed.v4i1.1601.
Tenti, D.C. (2019) Aktivitas Jus Buah Dewandaru terhadap Kepadatan Kolagen pada Mencit (Eugenia uniflora) Jantan. Akademi Farmasi Putera Indonesia Malang.
Tutik, T. et al. (2021) ‘Formulasi Sediaan Gel Moisturizer Anti-aging Ekstrak Kulit Bawang Merah (Alliium cepa L.) sebagai AntioksidanN’, Jurnal Farmasi Malahayati, 4(1), pp. 93–106. Available at: https://doi.org/10.33024/jfm.v4i1.4420.
Wahid, H., Karim, S.F. and Sari, N. (2022) ‘Formulasi Sediaan Krim Anti-aging dari Ekstrak Kolagen Limbah Sisik Ikan Bandeng (Chanos chanos)’, Jurnal Sains dan Kesehatan, 4(4), pp. 428–436. Available at: https://doi.org/10.25026/jsk.v4i4.1289.
Wijaya, H., Novitasari and Jubaidah, S. (2018) ‘Perbandingan Metode Ekstraksi Terhadap Rendemen Ekstrak Daun Rambui Laut (Sonneratia caseolaris L. Engl)’, Jurnal Ilmiah Manuntung, 4(1), pp. 79–83.
Zubaydah, W.O.S., Novianti, R. and Indalifiany, A. (2022) ‘Pengembangan dan pengujian sifat fisik sediaan spray gel darı ekstrak etanol batang Etlıngera rubroloba menggunakan basıs gel Na-CMC’, Journal Borneo, 2(2), pp. 38–49. Available at: https://doi.org/10.57174/jborn.v2i2.27.
Published
2024-05-31
How to Cite
SaputriR., AnwarM. R., NurhabibahQ., AgustinL., RahmawatiW. and AfikaZ. (2024) “FORMULASI DAN UJI AKTIVITAS ANTIPENUAAN SPRAY GEL KOMBINASI EKSTRAK KULIT SALAK DAN LIDAH BUAYA”, Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ, 11(2), pp. 84-92. doi: https://doi.org/10.32699/ppkm.v11i2.6958.
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Section
Penelitian
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